Popular song from 2004-2005 with "duet" between pop singer and high pitched cartoon characters

This has been bugging me that I can't find this. I remember this song being popular on the radio, and I remember on a field trip a big argument breaking out about whether the song was cool/funny or just incredibly annoying. I think it was a love/breakup song, but not positive. And it alternated between some pop singer, and high pitched cartoon character, maybe alvin and the chipmunks, or maybe someone else