Let's talk cholesterol and kidney function

Hey all-

Instead of an update on my status after 16+ months in the Triumph-1 trial I figured let's talk labs!

Oh and for those curious, my experience remains the same, minimal side effects, 31% weight loss, BMI of 23 just riding above the line for dose reduction. I'm eligible for the trial extension but my site said they'll decide to offer me or not in April which would be my second to last visit if I don't get extended.

Anyways, labs.

So I'm a nerd and have been tracking more than a few of my own labs in the trial and wanted to see if anyone else has had similar experiences

First up is cholesterol and lipids. I had quite high cholesterol when I started the trial and it was one reason I started, I wanted to see if I could get my cholesterol down. Well at this point, I consider that an accomplished goal. I've watched my cholesterol get lower and lower and lower with my trial labs and yesterday it reached a point I never thought it could. I had labs drawn by my PCP and my total cholesterol is now down 56% since the start of the trial.

Even more radical is my LDL cholesterol is down 63% I'm a nurse practitioner, I prescribe statins. These are things I see with high dose statins. The thing is I'm just on Reta. I am astonished. My total cholesterol is 116 my LDL cholesterol is 62.

Rounding it out my triglycerides are down 76%, my VLDL is down 74% and my HDL is up about 10%

The other thing I want to discuss is kidney function. My GFR which is the measure of how well you kidney are working and filtering has been consistently 15-20% elevated since the trial started. It was 128 yesterday. I started the trial at 105. And for years before the trial I was consistently about 100-105. This is also pretty unexpected in a very positive way. A potential increase/preservation of renal function would be unprecedented in the history of medicine.

So I'm curious, those of you who are lab nerds like me, what have you seen happen to your labs during the trial??