People who do full playthroughs with small pawn counts.. How do you do it?

I've been wanting to try and do a full playthrough with just small colony, but how the hell do you deal with the game trying to shove new pawns at you? I play with Combat extended and some other combat related mods..

Do you just take the hits on declining wanders and so forth or do you accept them and then send them on a death caravan before people like them? How do you deal with getting rid of all the extra pawns with out taking mood hits?