Why not always take Logan's Loophole?
I was thinking about it in my current run. Lvl 50 is overkill. A build usually focuses exclusively on one weapon or weapon type, you don't need 100 points in both guns and melee and unarmed.
Same goes for perks. Even at being capped at 15 perks I'm forced to pick stuff to because.
My build? I'm going to tank + crit + Vats + holorifle
S - 5 P - 5 E - 8 C - 1 I - 7 A - 5 L - 9
Traits - Logan + Built to Destroy
Perks
Bachelor - Most human enemies are male, so this is basically +10% damage
Rapid Reload - Great for any build really, free dps. Specially with weapons that load each round separately.
Toughness 1 and 2 - Free DT
Vigilant Recycler - Mandatory for energy weapon builds.
Commando - Not really needed but I'll be using Vats a lot.
Living anatomy - Not really needed but free damage and extra info on targets.
Stonewall - Great against deathclaws
Finesse - Free extra crit chance
Sniper - Again, not really needed but I use Vats a lot.
Chemist - Double the duration of drugs and stimpacks. This means that with Logan they will last 3x as long.
Better criticals - self explanatory
Meltdown - obligatory for any energy weapon build
Grim Reaper Sprint - Vats build etc etc
Implant GRX - Turbo is the most op drug and this is free turbo.
This is it really, 15 perks and I don't think I'm missing out on anything major that would give me extra damage.